CORDIS Project
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This project investigates the role of border-associated macrophages in the development of Parkinson's disease following influenza infection. It aims to understand how these immune cells contribute to neuroinflammation and α-synuclein propagation, potentially increasing the risk of neurodegeneration.
Parkinson’s disease (PD) is the fastest-growing neurodegenerative disease worldwide, characterized by the accumulation of α-synuclein (αSyn).
Evidence suggests two potential origins of αSyn pathology: brain-first or body-first initiation, with infection as possible trigger.
Epidemiological studies implicate influenza infection in increasing the risk of developing PD, but the precise cellular mechanisms remain unclear. I propose that border-associated macrophages (BAMs), residing at the interface…
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