CORDIS Project
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This project explores the maintenance of histone marks during DNA replication, focusing on H2A and H2B modifications. Using mouse embryonic stem cells, it aims to uncover mechanisms that ensure proper chromatin reestablishment and epigenetic inheritance.
Chromatin and its accompanying histone marks are fundamental for correct, cell type-specific gene expression and thus important to ensure cellular identity of each cell.
Importantly, this requires that the chromatin landscape is accurately propagated and maintained across DNA replication, a process which is still not well understood.
While there have been insights into how histone H3 and H4 marks are transmitted to daughter cells, information on H2A and H2B marks are still missing.
Using mouse e…
KOBENHAVNS UNIVERSITET
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