CORDIS Project
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This project investigates how mutations in the histone H3.3 variant affect brain cancer, specifically pediatric glioblastoma multiforme. It aims to understand the role of these mutations in altering chromatin structure and function, which may contribute to tumor development and maintenance.
Epigenetic reprogramming is a hallmark of brain cancer.
Remarkably, driver mutations of the histone H3.3 variant and its loading machinery have been recently found in paediatric glioblastoma multiforme (GBM), a devastating neoplasm originating from transformed neural precursors.
Thus, the very basic building blocks of chromatin can be mutated in cancer.The present challenge is to define at which level altered H3.3 loading influences GBM pathogenesis and provide clues into the underlying mechanis…
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United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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