CORDIS Project
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This project focuses on resolving haplotypes to link genetic variants with gene expression. By using advanced genomic techniques, the aim is to understand how genetic variations affect diseases, particularly breast cancer, and to explore the three-dimensional organization of genomes.
High-throughput sequencing methods are breaching the barrier of $1000 per genome.
This means that it will become feasible to sequence the genomes of many individual and create a deep catalog of the bulk of human genetic variation. A great task will lie in assigning function to all this genetic variation.
Genome wide association studies have already shown that 40% of all loci significantly associated with disease are found in intergenic, supposedly regulatory regions.
One of the current challenge…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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