CORDIS Project
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This project investigates the structural differences between human and chimpanzee non-coding RNAs to understand their role in human brain development. By analyzing RNA constructs and their dynamics, the research aims to uncover how specific genetic changes contribute to the evolution of human consciousness.
The 118-nt long human accelerated region 1 of humans (hHAR1F) possesses the largest genetic drift of all 49 so far identified HARs with an estimated 18 substitutions in comparison to the homologous sequence from the chimpanzee (cHAR1F).
In order to understand the unknown function of these non-coding RNAs in the development of human consciousness it is essential to elucidate their secondary and tertiary structures of the HAR RNA with atomic resolution.
We will design RNA constructs which will mim…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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