CORDIS Project
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This project aims to develop a mass spectrometry-based test to accurately quantify specific molecular forms of antithrombin, a key protein in blood coagulation. By identifying clinically relevant proteoforms, it seeks to standardize testing methods for better clinical outcomes in thrombosis management.
Current medical tests for antithrombin deficiency generally measure the overall activity, being blind for the actual proteoforms of AT that contribute to the test.
To ensure accurate test results, a traceability chain needs to be in place, which requires the accurate definition of the exact analyte to be measured. I hypothesize that an in-depth understanding of the pathological molecular proteoforms of antithrombin (AT) will allow for the identification of clinically relevant proteoforms and ena…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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