CORDIS Project
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This project investigates the role of the MOZ protein in blood cell development and its implications in leukemia. It utilizes a specially mutated mouse model to study the effects of MOZ's enzymatic activity on gene regulation and epigenetic changes.
The research programme will comprise the study of the Histone acetyl transferase (HAT) MOZ (Monocytic leukaemia Zinc finger) a critical player in the development and maintenance of the haematopoietic system.
In addition, translocations of MOZ are associated with Acute Myeloblastic Leukaemia.
Given the importance of this protein in haematopoiesis and leukaemogenesis, it would be essential to further understand the function of MOZ and in particular to identify the genes regulated by its HAT activi…
THE UNIVERSITY OF MANCHESTER
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