CORDIS Project
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This project investigates the structural and dynamic characteristics of the C-terminal domain of the Hepatitis B virus core protein, which is crucial for the viral life cycle. By using solid-state nuclear magnetic resonance, the project aims to elucidate the conformation and interactions of this domain, potentially lea…
We will seek in this project to reveal structural and dynamic features of the C-terminal domain (CTD) of the Hepatitis B virus (HBV) core protein which encapsidates the viral genome.
Each year, over 750,000 deaths are due to serious liver diseases caused by chronic HBV infection.
Hepatitis B is, despite the availability of a vaccine, still a major health problem.
The HBV virus particle is composed of an outer lipid-protein envelope and a core protein of 20 kDa that self-assembles into icosahedra…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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