CORDIS Project
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This project investigates the relationship between Hepatitis C Virus and lipid metabolism in the liver. It aims to understand how the virus manipulates lipid biogenesis and transport, which could lead to new therapeutic strategies for treating chronic infections and associated liver diseases.
Hepatitis C Virus (HCV) is a global problem infecting ~170 millions people and is a leading cause of liver transplantation.
Because of the lack of prophylactic vaccine and limitation of an effective therapy, persistent infection leads patients to chronic hepatitis, steatosis, cirrhosis and liver cancer. A body of evidence shows that the course of disease progression involves metabolic alteration of lipid biogenesis and homeostasis in the liver.
Furthermore, viral replication and egress are found…
UNIVERSITY OF LEEDS
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