CORDIS Project
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This project focuses on understanding the structure of the Kv11.1 potassium channel, crucial for heart function, using advanced imaging techniques. By producing a specific protein variant, the research aims to explore drug interactions and develop safer cancer therapies that target tumor-specific channel isoforms witho…
Potassium channels are widely distributed and have many important biological functions in the human body.
Of special interest is the Kv11.1 channel, whose main function is the repolarization of the membrane after a cardiac action potential.
Unfortunately, this channel can be blocked by a variety of structurally diverse drugs causing the long QT syndrome (LQTS), a cardiac repolarization disorder that can lead to arrhythmia and sudden heart death.
Due to this very severe side effect, a variety of…
UNIVERSITY OF LEEDS
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