CORDIS Project
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This project investigates the loss of chromosome Y in men, a mutation linked to increased disease risk and mortality. It aims to understand the cellular changes in immune cells caused by this loss, explore its association with various diseases, and develop detection tools to improve early diagnosis and treatment for af…
Men live shorter and are more susceptible to several common diseases at younger ages compared with women, but the reason(s) why are not well understood.
Loss of chromosome Y (LOY) is a male specific mutation that could help explain this sex bias.
Men with LOY carry a fraction of blood cells without the Y chromosome, due to its loss from progenitor cells during life time.
The incidence of LOY increases with age and can be detected in blood among 40% of 70 year old men.
My recent results show that…
UPPSALA UNIVERSITET
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