CORDIS Project
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This project investigates the interaction between the receptor tyrosine kinase KIT and the meteorin-like protein METRNL, aiming to understand their role in heart tissue regeneration. By exploring this novel signaling pathway, the research seeks to develop new therapeutic strategies for improving recovery from ischemic…
KIT, a receptor tyrosine kinase, is dimerized at the cell surface by the cytokine stem cell factor (SCF) to initiate signalling pathways securing fundamental cellular processes, including hematopoiesis, gametogenesis, and melanogenesis.
Impaired signalling due to KIT mutations or deficiency leads to various malignancies such as leukemia and melanoma.
However, recent data have shown that KIT can also initiate signalling by binding meteorin-like protein (METRNL), triggering unrelated stimulation o…
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Germany, Osnabrueck
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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