CORDIS Project
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This project investigates how modifications to DNA influence gene expression during the differentiation of stem cells into neurons. By employing advanced proteomics and genomics techniques, it aims to uncover the proteins that interact with modified DNA and their role in regulating developmental processes.
(Hydroxy)methylation of cytosine residues in eukaryotic DNA represents a major means to regulate gene expression during development.
These modifications are considered to be epigenetic marks, since they have a profound impact on phenotype, but are inherited from mother to daughter cells independent of the underlying DNA sequence.
Large efforts are currently underway to profile genome-wide DNA (hydroxy)methylation patterns in model organisms and in clinical studies, since aberrant DNA (hydroxy)me…
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Netherlands, Utrecht
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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