CORDIS Project
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This project investigates the role of the Hedgehog signaling pathway in human liver cancer, particularly focusing on its influence on liver stem cells and cancer development. Using transgenic animal models, the research aims to identify new therapeutic targets for treating hepatocellular carcinoma, a highly lethal form…
The incidence of Human Hepatocellular Carcinoma (HCC) has been constantly increasing over last decades.
Owing one of the highest mortality rates among cancers the HCC is resistant to the conventional cancer treatments.
Therefore new approaches to treat this disease are vitally needed.
The Hedgehog (HH) pathway has been recently implicated in the pathogenesis of several human cancers including those of the gastrointestinal tract.
There is evidence that the HH pathway might be important in regulat…
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