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The HEGEMONIC project investigates the genetic factors contributing to hepatocellular carcinoma, a common liver cancer. By analyzing rare genetic variants using advanced sequencing techniques, it aims to identify new biomarkers and potential treatment targets.
Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide.
Although several environmental factors have been identified, many affected individuals never develop HCC, suggesting a genetic susceptibility.
Candidate genes and genome-wide association studies (GWAS) have only uncovered a few variants reproducibly linked to HCC. GWAS design typically allows the detection of common variants that usually have small effect sizes.
Even taken together, they explain a very limi…
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