CORDIS Project
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This project seeks to convert liver cells into insulin-producing pancreatic cells to address diabetes. It will investigate the developmental pathways and genetic factors that determine cell fate during early development.
Diabetes is a degenerative disease affecting millions of persons worldwide. A cure for diabetes depends on replacing the insulin-producing ²-cells in the pancreas that are destroyed by the disease.
An attractive strategy to attain this goal is to convert liver adult cells of the same patient into pancreatic ²-cells.
The liver and pancreas share many aspects of their early development and are specified in adjacent regions of the endoderm, possibly from a common bipotent progenitor cell.
Therefore…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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