CORDIS Project
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The HERMIONE-2MAN project builds on previous findings about dependence receptors that can induce cell death in the absence of ligands. It aims to develop an anti-cancer drug targeting netrin-1 interactions, with the goal of initiating clinical trials to evaluate its safety and efficacy in cancer treatment.
It is usually assumed that transmembrane receptors are inactive unless bound by their respective ligand.
Against this dogma, the CLB proposed that some receptors may also be active in the absence of ligand and in this case trigger cell death.
These receptors were called dependence receptors (DR) as their expression at the cell surface leads the cell to be dependent for its survival on ligand availability.
The prototypic DRs are receptors DCC and UNC5H that bind their ligand netrin-1.
The FP6 HER…
CENTRE DE LUTTE CONTRE LE CANCER LEON BERARD
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
France, Lyon
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria, Klosterneuburg
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
Belgium, Bruxelles / Brussel
Type: Research institute
Activity type: Research Organisations
SME: No
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