CORDIS Project
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This project investigates why some healthy individuals develop severe infections from Group A streptococcus (GAS). By analyzing genetic factors and host-pathogen interactions, it aims to identify specific gene defects that increase susceptibility to invasive GAS infections.
Group A streptococcus (GAS) is a major, human specific, bacterial pathogen.
Most people suffer from mild infections, while only a few develop invasive GAS (iGAS) infections.
These cases of iGAS infections are unexplained as they strike otherwise healthy people.
The human specificity of GAS and the interindividual variability upon infection with GAS are poorly understood.
My proposal aims to close both knowledge gaps:
I hypothesize that single-gene defects of antistreptococcal immunity increase s…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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