CORDIS Project
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This project aims to investigate genetic mutations in children with severe Staphylococcus aureus infections. By analyzing the genetic basis of immunity, it seeks to understand the relationship between host genetics and susceptibility to bacterial infections, potentially informing future treatments and vaccines.
Staphylococcus aureus is one of the most important bacterial pathogens impacting human health.
Beta-barrel pore-forming toxins (BB-PFTs) are major virulence factors of S. aureus that destroy phagocytes, key effectors of immunity during staphylococcal infection, in a receptor-specific manner.
Acquired immunity to a specific compound of S. aureus, LTA, can rescue an inborn error of the TLR2 pathway (TIRAP deficiency). I hypothesize that severe staphylococcal infections during childhood, at least i…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION
United States, New York
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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