CORDIS Project
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This project focuses on developing selective inhibitors for Hhat, a key enzyme in the Hedgehog signaling pathway, which is important in cancer therapy. By creating high-potency compounds, the project aims to address resistance issues encountered with existing treatments and validate Hhat as a therapeutic target.
Being the first or second most common cause of premature death in over 100 countries, cancer imposes a major burden on modern societies worldwide.
Inhibition of the Hedgehog pathway has had success, both in vitro and in the clinic, but resistance is a commonly encountered problem, making alternative Hedgehog modulators in high demand.
Hhat is a membrane associated O-acyl transferase (MBOAT) whose only known function is the palmitoylation of Hedgehog, a posttranslational modification crucial for…
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