CORDIS Project
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This project investigates the mechanisms of synaptic remodeling during hibernation in hamsters to understand how these processes can reverse synaptic loss associated with dementia. By identifying human gene counterparts, the research aims to develop new therapeutic strategies to combat Tau-induced neurodegeneration.
Dementia is an enormous burden on society.
Patients require life-long care and there is no cure or symptomatic treatment.
At early phases, dementia is closely associated with synaptic degeneration and this correlates well with Tau pathology in >20 Tauopathies.
Interestingly, historic observations in hamsters and squirrels show that when they enter into hibernation, they also display Tau pathology and synaptic loss.
Pathologists have pointed to these similarities; however, there is an important d…
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