CORDIS Project
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This project investigates the role of natural killer cells in individuals who can control HIV without ongoing treatment. It aims to understand how genetic factors influence these immune responses and the potential for developing new therapies for HIV remission.
Antiretroviral therapy (ART) blocks HIV replication but cannot eliminate viral reservoirs that originate viral rebound if ART is discontinued.
However, the host laboratory originally described some individuals, post-treatment controllers (PTC), capable to durably control viremia after ART discontinuation.
More recently, the group has found that HLA B*35 alleles (usually associated with rapid progression in the absence of ART) are paradoxicaly overrepresented in PTCs and are accompanied with an M…
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