CORDIS Project
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This project investigates the roles of Hypoxia-Inducible Factors (HIF) in immune response and iron metabolism, particularly in relation to cancer and bacterial infections. It aims to understand how HIFs regulate iron homeostasis and contribute to tumor development, using specialized mouse models to explore these mechan…
HIF transcription factors, central mediators of cellular adaptation to critically low oxygen levels (=hypoxia), have been largely studied for their crucial role during cancer development.
Our recent findings have unveiled two new major roles of HIF.
First, in innate immunity and infection, we demonstrated the key contributions of HIFs in regulating important immune effectors molecules.
Second, we highlighted the role of HIFs in iron metabolism as critical regulators of iron absorption in the int…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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