CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates how specific mutations in histone H3.3 affect DNA damage response and genome stability, which are critical in cancer development. By studying these mutations in human cell lines, the project aims to uncover their role in tumorigenesis and potential implications for targeted cancer therapies.
Genome instability is a hallmark of cancer and is caused by the accumulation of DNA damage.
Genome integrity is preserved by DNA repair machineries that operate on a chromatin substrate where DNA wraps around histone proteins.
Interestingly, point mutations in histone H3.3 in particular have been identified as drivers of tumorigenesis.
Beyond their impact on gene expression, some of these mutations were recently shown to inhibit homologous recombination-mediated repair of DNA double-strand break…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
