CORDIS Project
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This project investigates the role of the Pbx1 and Hox11 proteins in the development of the spleen, focusing on their impact on cellular proliferation and differentiation during lymphoid organ formation. By analyzing genetic networks and target genes, the research aims to uncover the mechanisms underlying spleen agenes…
Lymphoid organ development results from a complex interplay of genetically controlled molecular and cellular networks.
While most of the molecular mechanisms underlying lymphoid organogenesis remain unknown, recent findings demonstrate that homeodomain transcription factors are essential to these processes.
One such homeoprotein is Pbx1 that binds DNA with a subset of Hox proteins, including the Hox11 oncoprotein aberrantly accumulated in T-cell acute leukemia.
Like Hox11, Pbx1 was originally is…
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
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