CORDIS Project
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This project investigates how transcription factors, specifically TEAD and FOX groups, interact and cooperate in regulating gene expression influenced by the HIPPO signaling pathway. It combines bioinformatics and experimental techniques to explore their binding mechanisms and structural characteristics, aiming to enha…
Transcription factors (TFs) are proteins which recognize specific DNA-sequence to orchestrate various gene expression programs according to cellular requirements.
Currently, approximately 1,600 TFs along with their binding motifs have been annotated.
Further, recent studies enabled classification of many of them according to their binding modes across nucleosome assembly.
Despite such progress, interplay of different TFs in the context of adjacent DNA sequence or spatial organisation of chromati…
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