CORDIS Project
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TransCure bioServices develops the His-Li-mouse, a humanized mouse model for preclinical drug testing. This model aims to improve the accuracy of drug safety evaluations and reduce the high failure rates in clinical trials.
Preclinical toxicology evaluation is the most critical step in pharmaceutical drug development, representing about 21.2% of the total drug development costs.
About 70% of drug development programs fail due to toxicity or unexpected issues in Absorption, Distribution, Metabolism, and Excretion (ADME) at Phase 1 validation on humans.
The main problem lies on the lack of accurate and reliable pre-clinical mouse models: in fact, current models fail to reflect human liver physiology, and often lead t…
TRANSCURE BIOSERVICES SAS
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