CORDIS Project
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This project investigates the role of specific histone modifications in the DNA damage response, focusing on histone H3K79 and H4K20 methylation. It aims to understand how these modifications influence the recruitment of DNA repair factors and chromatin reassembly, using both in vitro cell cultures and knockout mouse m…
After DNA damage a signal must be created to recruit DNA repair factors to the lesion.
Then the repair machinery needs to gain access to DNA and chromatin should be properly reassembled. DNA assembly with histones to form chromatin creates a physically limits the access to DNA.
Alterations of chromatin that do not affect the DNA sequence constitute the epigenetic level of regulation of DNA metabolism.
Among them, the post-translational modification of histones can directly regulate chromatin str…
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