CORDIS Project
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The project aims to understand the epigenetic reprogramming of primordial germ cells in mice, focusing on the role of the histone variant H3.3 and its chaperone HIRA. It employs advanced imaging techniques to observe chromatin dynamics during cell development.
The germ cell lineage gives rise to the gametes, which ensures the transmission of genetic and epigenetic information to the subsequent generation.
In mice, the foundation of the germ cell lineage is based on the specification of primordial germ cells (PGCs) during embryonic development.
Following specification, PGCs are epigenetically reprogrammed by active DNA demethylation and chromatin remodelling resetting the epigenome for acquiring totipotency.
However, the underlying mechanisms of PGC re…
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