CORDIS Project
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This project investigates how dendritic cells, which play a key role in immune response, protect themselves from HIV infection. It focuses on understanding the mechanism of a protein called SAMHD1 and its role in immune activation against HIV, aiming to uncover why current treatments struggle to eradicate the virus.
Dendritic cells (DC) are the front-line of virus detection and trigger the response of the innate and adaptive immune system. DCs "patrol" in the body and seek pathogens such as viruses.
When they catch viruses, they initiate immune responses primarily in lymph nodes and lymphoid tissue. DCs acquire a mature phenotype while they migrate towards the lymphoid tissues in order to process and present the antigens derived from viruses.
They also produce various cytokines and chemokines, substances wi…
INSTITUT PASTEUR
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