CORDIS Project
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This study explores the immune response of individuals who can control HIV without specific genetic markers. It focuses on the role of CD8+ T cells and other immune mechanisms, aiming to uncover how these individuals manage to suppress the virus effectively.
Infection with the human immunodeficiency virus (HIV) is eventually fatal in the absence of antiretroviral therapy.
However, approximately 0.3% of patients have the ability to efficiently control the virus for long periods without treatment (elite controllers).
It has been shown that HLA class I restricted CD8+ T cells play a crucial role in this process.
There is a strong genetic association between the ability to control the virus and certain alleles of the HLA-B complex (particularly HLA-B*27…
LEIBNIZ-INSTITUT FUR VIROLOGIE
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