CORDIS Project
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This project investigates the dynamics of Holliday junctions, which are critical structures in DNA repair. By employing advanced techniques, it aims to understand how these junctions behave within cells, which could enhance our knowledge of genomic stability and cancer biology.
omologous recombination (HR) is a DNA repair pathway that plays a central role in the maintenance of genomic stability and cancer prevention.
In the late stages of HR, recombination intermediates (Holliday junctions, HJs) need to be resolved to allow proper chromosome segregation.
Whilst HJ processing reactions have been well characterised in vitro, there is limited knowledge of the dynamic properties of these structures within a cellular context.
To explore the biological properties of HJs in v…
THE FRANCIS CRICK INSTITUTE LIMITED
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