CORDIS Project
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This project investigates non-canonical interactions in nucleic acids, focusing on their roles in biological processes. It aims to develop a model that accurately describes these interactions at near-atomic resolution, which could advance understanding in molecular biology and medicine.
This proposal concerns the study of non-canonical interactions in nucleic acids.
These interactions, also known as non-Watson-Crick base pairing, involve single or multiple DNA or RNA strands and are increasingly recognized as having a variety of essential roles in replication forks, telomeres, and gene regulation.
Since these processes occur on spatial and time scales beyond the reach of current computational capabilities, we propose to develop an innovative coarse-grain approach to describe th…
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