CORDIS Project
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This project aims to develop host-directed therapies for tuberculosis by identifying human genes involved in immune responses to the infection. Using CRISPR technology, it seeks to uncover critical pathways that could lead to new treatment targets.
With more than 10 million cases annually, tuberculosis (TB) remains a global health problem. TB epidemic is exacerbated by the spread of multidrug-resistant TB.
Host-directed therapies (HDTs) can improve immune mechanisms by augmenting the ability of host cells to kill M. tuberculosis (Mtb) or by modulating the immune response to prevent excessive inflammation, cell death and tissue damage.
Progress with HDT development has been slowed down by the limited understanding of host-pathogen interacti…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Netherlands, Amsterdam
Type: Research institute
Activity type: Research Organisations
SME: No
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