CORDIS Project
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This project aims to improve cancer treatment by identifying host responses to chemotherapy that promote tumor growth. It seeks to discover biomarkers for treatment outcomes and develop strategies to enhance the efficacy of anti-cancer drugs.
Chemotherapy remains one of the most common treatment modalities for cancer.
It is typically administered in cycles of bolus injections following 21 days of drug-free break periods.
However, tumor regrowth between drug intervals is often observed, due in part, to rebound angiogenesis.
Our previous studies demonstrated that bone marrow derived proangiogenic cells are acutely mobilized following certain chemotherapy treatments, accompanied by enhanced tumor angiogenesis, which can be blocked by pr…
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