CORDIS Project
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This project examines the interactions between transposable elements and host genomes, particularly in germline development. It aims to understand how these elements can influence reproductive success and their implications for diseases.
Transposable elements (TEs) are mobile DNA sequences that have massively colonized mammalian genomes.
Host genomes and TEs are engaged in ambiguous trade-offs, whereby TEs can be co-opted for genomic upgrades over evolutionary timescales, but they should also be suppressed to protect genome stability and function.
Effective and multi-layered surveillance is primordial:
TE reactivation is associated with various dysfunctional states, including infertility, ageing, cancer or neurological disorders…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Paris
Type: Research institute
Activity type: Research Organisations
SME: No
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