CORDIS Project
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This project investigates the formation and function of specialized nuclear hotspots that enhance gene transcription during zebrafish embryogenesis. By studying two long-lived hotspots, the research aims to uncover the mechanisms behind their creation and their role in gene expression activation.
There is accumulating evidence for a new gene expression paradigm, in which genes and transcription factors cooperate to create specialized nuclear hotspots optimized for transcription.
How hotspots form, and how they impact transcription, however, is unclear.
This is mostly because mechanistic and functional approaches have been limited by the large number of hotspots per nucleus, their small size, and their transient nature.
Here, wThere is accumulating evidence for a new gene expression parad…
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