CORDIS Project
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The project focuses on developing efficient synthetic methods for creating a unique class of compounds called housanes, which are fused cyclopropane and cyclobutane structures. By utilizing a novel catalytic process, the project aims to enhance drug development by improving the metabolic stability and pharmacokinetics…
Aliphatic sp3-rich ring systems such as cyclopropanes and cyclobutanes are commonly observed motif in drug molecules.
This is due to the fact that they can positively influence metabolic stability, conformation, pKa, entropy, membrane permeability or pharmacokinetics in drug leads.
However, the molecule consists of a cyclopropane fused to cyclobutane, traditionally known as ‘housane’ is significantly underexplored and yet to appear in drug molecules.
This can largely be attributed to the lack of…
FUNDACION PRIVADA INSITUTO CATALAN DE INVESTIGACION QUIMICA ICIQ
FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
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Spain, Madrid
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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