CORDIS Project
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This project investigates how pre-replicative complexes (pre-RCs) regulate DNA replication and contribute to genetic instability in cancer and normal development. By using advanced genome editing and cellular models, it aims to uncover the signaling pathways involved in these processes, potentially leading to new cance…
The development of the human body starts from a single cell, fertilized egg, which divides about ten trillion times to form an adult human.
During every cell division, the genome is duplicated with great accuracy by DNA replication and distributed with one copy to each of the two daughter cells.
Understanding how the cell regulates DNA replication remains one of the most fundamental questions in biomedicine, because up to two-thirds of all cancers are caused by accumulation of errors during DNA…
BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY
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