CORDIS Project
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This project focuses on improving hematopoietic stem cell therapies by using advanced CRISPR technology to manipulate gene expression. By enhancing pathways related to gene editing, self-renewal, and bone marrow homing, the research aims to overcome challenges in both allogeneic and autologous stem cell transplantation…
Hematopoietic stem cells (HSCs) reside in the bone marrow where they throughout life sustain continuous blood production through a controlled balance of differentiation and self-renewal.
Transplantation of HSCs from a healthy person can replace a defective hematopoietic system of a patient thereby curing the patient for life. HSCs have found increasing therapeutic application, e.g. in hematologic malignancies and hematopoietic genetic disorders.
This applies not only to the allogeneic transplant…
AARHUS UNIVERSITET
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