CORDIS Project
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This project aims to develop methods for generating and expanding hematopoietic stem cells from patient-specific induced pluripotent stem cells. By understanding the molecular mechanisms of embryonic stem cell development, the project seeks to overcome barriers in stem cell transplantation and enhance the application o…
Although hematopoietic stem cell (HSCs) transplantation is routinely used to treat blood disorders, immune incompatibility and donor shortage remain critical clinical barriers.
Likewise, since high number of HSCs are needed for successful transplants, the absence of reliable expansion protocols prevents the wider application of this cell therapy.
In fact, while HSC-based gene therapy represents a revolutionary treatment also for novel and unexpected indications, the ex vivo manipulation required…
OSPEDALE SAN RAFFAELE SRL
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