CORDIS Project
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This project focuses on understanding the behavior of haematopoietic stem cells in their bone marrow niches. By using advanced microscopy, it aims to visualize these cells in real time and explore how their environment influences their function and fate during infections and leukemia.
Haematopoietic stem cells (HSC) reside in the bone marrow, from where they maintain immune cells, erythrocytes and platelets.
To function correctly, they depend on their localisation within highly specialised niches, where cell-cell and -matrix interactions as well as medium- and long-range molecular signals are integrated to instruct them to either remain quiescent, or to generate progeny that will maintain both the stem cell pool and the differentiated lineages.
Studies based on HSC transplant…
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