CORDIS Project
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This project explores the molecular mechanisms behind protein misfolding and aggregation, particularly focusing on the interaction between alpha-synuclein and the chaperone Hsp70. By employing various biophysical and biochemical techniques, it aims to provide insights into neurodegenerative diseases like Alzheimer's an…
Protein misfolding and aggregation are associated with a wide range of severe, and so far incurable, neurological and systemic disorders, which include Alzheimer's and Parkinson's diseases, and type II diabetes.
As these conditions are the consequence of the impairment of protein homeostasis, a variety of cellular natural defenses have evolved to eliminate protein aggregates as they form.
In this application we are concerned with the problem of understanding the molecular basis of such defense m…
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