CORDIS Project
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This project investigates the heat shock response in eukaryotes by studying a non-coding RNA that activates the heat shock transcription factor. It aims to prepare a recombinant RNA-protein complex for structural analysis, which could provide insights into RNA function and potential therapeutic applications in cancer t…
The heat shock response is important in eukaryotes as a protective mechanism for the stress of change in temperature or other environmental factors, and it has been the subject for targets for therapeutic intervention.
Recently, it has been found that a conserved non-coding RNA is involved in mediating the heat shock response.
The RNA forms a stable complex with elongation factor eEF1A to activate the heat shock transcription factor.
The project will involve the preparation of recombinant RNA-pr…
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