CORDIS Project
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This project develops a high-throughput platform for directed evolution of therapeutic proteins, focusing on enhancing their stability and reducing aggregation. It combines advanced techniques to evaluate protein variants in a controlled environment.
The project will establish a novel high-throughput directed evolution platform for evaluating large libraries of therapeutic protein (TP) variants for increased thermostability, slower global or local unfolding rates, and minimised aggregation propensity.
This will require several recent advances to be coupled into a single system.
Directed evolution can be carried out by encapsulating single plasmids, each encoding a unique protein variant, into droplets of an emulsion, then using cell-free exp…
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