CORDIS Project
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This project focuses on understanding human ribosome biogenesis, a complex process involving numerous factors and small nucleolar RNAs. Using advanced imaging and sequencing techniques, it aims to create a detailed structural inventory of ribosome assembly in human cells.
The emergence of numerous diseases caused by defective assembly of ribosomes calls for a deeper understanding of human ribosome biogenesis.
Yet, in human cells the assembly of ribosomal subunits is a vital process of daunting complexity, which requires several hundreds of assembly factors (AFs).
Together with small nucleolar RNAs (snoRNAs) these factors facilitate a cascade of modification, processing and folding events of the ribosomal RNA (rRNA) that are tightly coordinated with the incorporat…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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