CORDIS Project
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This project investigates the role of specific microglial subpopulations in the early stages of Alzheimer's disease by analyzing neuron-glia interactions in human brain samples. It aims to identify how these glial cells contribute to neuronal dysfunction and cognitive decline, potentially leading to new biomarkers for…
The molecular mechanisms leading to Alzheimer's disease (AD) are poorly understood.
This is due to lack of human tissue samples for research representing early changes of AD pathology.
The accumulating pathology, including beta-amyloid and tau proteins, are manifested by concomitant neuroinflammatory reactions geared by malfunctional microglia.
Microglia in the human and mouse AD brain exist in various subpopulations from which a specific, disease-associated microglia population is thought to be…
UNIVERSITY OF EASTERN FINLAND (UEF)
ITA-SUOMEN YLIOPISTO
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