CORDIS Project
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The HumBrain project aims to create a detailed model of the P-glycoprotein pump within the blood-brain barrier to understand its role in drug resistance and delivery challenges for central nervous system disorders. By using advanced simulations, the project seeks to inform the development of new treatments for conditio…
The blood-brain barrier (BBB) is a complex interface that separates the central nervous system (CNS) from the circulatory system and serves to maintain brain homeostasis.
There are native P-glycoprotein (P-gp) transporters embedded in the BBB endothelial cell membranes, which play a fundamental role in effluxing out xenobiotics.
Such protections come at a steep price, since the BBB is a key roadblock in the delivery of treatments for CNS disorder, including brain tumors and Alzheimer’s, while th…
AARHUS UNIVERSITET
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