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The HumEn project focuses on generating insulin-producing beta cells from human stem cells to address diabetes treatment needs. By studying endodermal progenitor cells, the project aims to develop reliable methods for producing functional beta cells for potential clinical applications.
Despite progress in producing beta cells from human pluripotent stem cells (hPSCs) in recent years, full differentiation cannot be obtained in vitro.
The HumEn project hypothesises that a fundamental understanding of the coupling between endodermal progenitor expansion and differentiation is relevant for elucidating how to a) generate glucose-responsive beta cells from hPSCs in vitro, and b) generate sufficient number of beta cells to meet future clinical needs in cell therapy in diabetes.
Thus,…
KOBENHAVNS UNIVERSITET
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