CORDIS Project
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This project aims to understand the variations in pancreatic β-cell states related to type 2 diabetes by creating a Human Pancreatic Islet Perturbation Atlas. It will utilize single-cell multiomics and statistical tools to analyze how these cells respond to different perturbations, ultimately seeking to identify new th…
Type 2 diabetes (or T2D) is a heterogeneous disease that affects nearly 1 in 10 adults worldwide, directly causing 1.5 million deaths each year.
Human genetics and single cell genomic studies show that abnormal pancreatic β-cell transcriptional programs play a crucial role in type 2 diabetes.
However, we lack an understanding of how this is translated into impaired β-cell function or mass.
Consequently, existing drug therapies for T2D aim to alleviate hyperglycaemia, but do not target causal mec…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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